Challenge

PLAMORF focuses on Plant Mobile RNAs: Function, Transport and Features.

An essential consequence of multi-cellularity is the need for intercellular and tissue-wide communication, which happens through transport of signalling molecules. In higher plants long-distance transport of signalling molecules occurs mainly via  the phloem.

In addition to small molecules, a remarkably large number of macromolecules such as micro RNAs (miRNAs), protein producing messenger RNAs (mRNAs), and RNA-binding proteins (RBPs) have been identified in the phloem, representing additional classes of signalling molecules.

Research questions and approach

  • How are mobile RNAs selected for transport?
  • How specific is RNA mobility?
  • What determines their destination?
  • How are these signals processed in the destination cells?

We develop predictive models, using single cell transcriptomics to establish cell-type specific RNA transport and motifs, and study the structure, affinity, and functions of phloem transported RNAs associated proteins. We combine the advantages of the agronomically important oilseed rape with the well-established A. thaliana belonging to the same plant family.

The ERC

PLAMORF is funded by the European Research Council (ERC). The ERC, set up by the EU in 2007, is the premiere European funding organisation for excellent frontier research. Every year, it selects and funds the very best, creative researchers of any nationality and age, to run projects based in Europe.

The ERC offers four core grant schemes: Starting, Consolidator, Advanced and Synergy Grants. With its additional Proof of Concept grant scheme, the ERC helps grantees to bridge the gap between grantees’ pioneering research and early phases of its commercialisation.

PLAMORF is…

Objectives

Consortium

News & Blog

PUBLICATION: The glycine-rich domain of GRP7 plays a crucial role in binding long RNAs and facilitating phase separation

Microscale thermophoresis reveals the RNA binding properties of glycine-rich RNA binding protein 7 (GRP7)
Structural and functional analysis of a plant nucleolar RNA chaperone‑like protein

PUBLICATION! Structural and functional analysis of a plant nucleolar RNA chaperone‑like protein

NURC1 localizes to the nucleolus of plant cell nuclei, exhibits RNA chaperone‑like activity and may have a function in pre‑rRNA processing and thus ribosome biogenesis.

8 August 2023, Plant Biology 2023 in Savannah, Georgia

PLAMORF PI is one of the plenary speakers of Plant Biology 2023 (ASPB) meeting on the topic of long-distance travel of messenger RNAs.

PLAMORF in a nutshell

Fact box

Title: Plant mobile RNAs: function, transport and features (PLAMORF)
Start: 1.4.2019
Duration: 6 years
Keywords: plant, tranport, mobile RNA, signalling, phloem, RNA-binding proteins, oilseed rape, A. thaliana
Budget: 6.1 million
Funding: ERC synergy grant

Research groups:

Friedrich Kragler, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Golm, Germany
Julia Kehr, Universität Hamburg, Hamburg, Germany
Richard Morris, John Innes Centre, Norwich, United Kingdom

 

Acknowledgements

This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 810131)