PLAMORF: Long-distance RNA signalling in plants

Consortium

Objectives

PLAMORF is…

Challenge

PLAMORF focuses on Plant Mobile RNAs: Function, Transport and Features.

An essential consequence of multi-cellularity is the need for intercellular and tissue-wide communication, which happens through transport of signalling molecules. In higher plants long-distance transport of signalling molecules occurs mainly via  the phloem.

In addition to small molecules, a remarkably large number of macromolecules such as micro RNAs (miRNAs), protein producing messenger RNAs (mRNAs), and RNA-binding proteins (RBPs) have been identified in the phloem, representing additional classes of signalling molecules.

Research questions and approach

  • How are mobile RNAs selected for transport?
  • How specific is RNA mobility?
  • What determines their destination?
  • How are these signals processed in the destination cells?

We develop predictive models, using single cell transcriptomics to establish cell-type specific RNA transport and motifs, and study the structure, affinity, and functions of phloem transported RNAs associated proteins. We combine the advantages of the agronomically important oilseed rape with the well-established A. thaliana belonging to the same plant family.

The ERC

PLAMORF is funded by the European Research Council (ERC). The ERC, set up by the EU in 2007, is the premiere European funding organisation for excellent frontier research. Every year, it selects and funds the very best, creative researchers of any nationality and age, to run projects based in Europe.

The ERC offers four core grant schemes: Starting, Consolidator, Advanced and Synergy Grants. With its additional Proof of Concept grant scheme, the ERC helps grantees to bridge the gap between grantees’ pioneering research and early phases of its commercialisation.

News & Blog

PUBLICATION: First characterisation of phloem-associated RNA chaperone-like protein (PARCL)

Intrinsically disordered plant protein PARCL co-localizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD.

29.8 – 2.9, Lyon, Plant Computational Biology workshop

The Plant Computational Biology workshop is a satellite event to the 20th Plant Biomechanics conference, one of the invited speakers is PLAMORF PI Richard Morris.

Meet PLAMORF scientists at PVB 2022

The sixth international conference on Plant Vascular Biology in Berlin, Germany is a great opportunity to meet PLAMORF scientists! All three PIs and several other project members are joining: Friedrich Kragler, Julia Kehr, Richard Morris, Steffen Ostendorp, Andras Szekely...

Twitter feed

🥂Congratulations! PLAMORF scientist Ying Xu, now Dr. Ying Xu, successfully defended her PhD thesis on #RNA #transport! #phdlife #plantsci https://t.co/SAHviFc5iT
@plamorf
@qpb_journal: #QPB's mission is to become the venue for plant biologists, bio-engineers, and mathematical/computational/physical scientists to publish their data collection, collation and analysis of the plant sciences. Learn more about us today: https://t.co/lPIUaKOUqY https://t.co/92zCkobnjH
@plamorf
@JohnInnesCentre: NEWS - Applications are now OPEN. Independent Research Fellowships Leading to Tenured Faculty Positions at the John Innes Centre (JIC) Closing date – Friday 25th November 2022 For more info: https://t.co/pkQvVoaWk1 https://t.co/5rRdNI8t9c
@plamorf

PLAMORF in a nutshell

Fact box

Title: Plant mobile RNAs: function, transport and features (PLAMORF)
Start: 1.4.2019
Duration: 6 years
Keywords: plant, tranport, mobile RNA, signalling, phloem, RNA-binding proteins, oilseed rape, A. thaliana
Budget: 6.1 million
Funding: ERC synergy grant

Research groups:

Friedrich Kragler, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Golm, Germany
Julia Kehr, Universität Hamburg, Hamburg, Germany
Richard Morris, John Innes Centre, Norwich, United Kingdom

 

Acknowledgements

This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 810131)